Yadav’s main research mission is to understand intricate organ connections using mouse and human studies, aiming to find innovative treatments for bone and metabolic disorders.
The lab explores how different organs in the body connect, especially focusing on the skeleton's interactions. Think of the skeleton like a house, constantly affected by internal and external factors. Just as a house can weaken from sun, rain, or rust, bones can deteriorate from various influences. A notable example is post-menopause bone loss due to reduced estrogen, showing how organs impact bone health. The skeleton also sends out signals, like the hormone osteocalcin, affecting other organs and overall body health.
Recently, they discovered a unique connection between the gut, liver, and bones via vitamin B12. Through mouse studies, they learned that B12 in the liver influences bone growth. This finding suggests new potential treatments for bone conditions like osteoporosis.
Here, we discuss Dr. Yadav’s 10-year project looking at the non-essential amino acid, taurine, on healthspan and longevity.
Taurine and Biological Aging. Podcast with Vijay Yadav.
For many of you out there, taurine probably first registers in your mind as an ingredient in popular energy drinks and pre-workout supplements. (This is actually somewhat ironic, since taurine is not a stimulant, and is likely to have, if anything, the opposite effect.)